كتابة النص: الأستاذ الدكتور يوسف أبو العدوس - جامعة جرش قراءة النص: الدكتور أحمد أبو دلو - جامعة اليرموك مونتاج وإخراج : الدكتور محمد أبوشقير، حمزة الناطور، علي ميّاس تصوير : الأستاذ أحمد الصمادي الإشراف العام: الأستاذ الدكتور يوسف أبو العدوس
فيديو بمناسبة الإسراء والمعراج - إحتفال كلية الشريعة بجامعة جرش 2019 - 1440
فيديو بمناسبة ذكرى المولد النبوي الشريف- مونتاج وإخراج الدكتور محمد أبوشقير- كلية تكنولوجيا المعلومات
التميز في مجالات التعليم والبحث العلمي، وخدمة المجتمع، والارتقاء لمصاف الجامعات المرموقة محليا واقليميا وعالميا.
المساهمة في بناء مجتمع المعرفة وتطوره من خلال إيجاد بيئة جامعية، وشراكة مجتمعية محفزة للابداع، وحرية الفكر والتعبير، ومواكبة التطورات التقنية في مجال التعليم، ومن ثم رفد المجتمع بما يحتاجه من موارد بشرية مؤهلة وملائمة لاحتياجات سوق العمل.
تلتزم الجامعة بترسيخ القيم الجوهرية التالية: الإلتزام الإجتماعي والأخلاقي، الإنتماء،العدالة والمساواة، الإبداع، الجودة والتميّز، الشفافية والمحاسبة، الحرية المنظبطة والمستقبلية.
التخصص العام: علم الحيوان- العلوم البيولوجية
التخصص الدقيق: التقنيات النسجية وسمية الجسيمات النانوية
جامعة التخرج: جامعة الخرطوم سنة 1999م
الاهتمام البحثي: التغيرات النسيجية والكيميانسيجية وفي التراكيب الدقيقة التي تحدثها بعض الأدوية والملوثات والجسيمات النانوية
البحوث المنشورة: 99 بحثاً
الكتب الؤلفة: 36 كتاباً
Name : Prof. Bashir M. Jarrar
Nationality: Jordanian
Major: Biology – Zoology
Specialization Fields: Histocytotechnology and Nanotoxicity
Education
University of Khartoum
Thesis Title: Histological, Histochemical and Ultrastructural
Alterations Induced by Lead in the Kidney and Liverof Male Wistar Albino Rats
M.Sc. degree in Biology,
University of Jordan
Jordan
Employment Record
Biology Deprtment
College of Science
Jerash University
Full Professor -
Medical Laboratory Sciences Department
College of Applied Medical Science
Al-Jouf University
Teaching and Research fellow
Histology andHistochemistry Unite, Zoology Department
King Saud University
Lecturer in Histocytotechnology
Health College–Riyadh
Ministry of Health
Saudi Arabia
Al-Hikma Drug Factory, Jordan
Histocytopathology Laboratories
AI-Khaldi Hospital, Amman
Jordan.
Histopathology Laboratories
College of Medicine
THe university of Jordan
:I taught or have been teaching the following courses
Biology Couse: Human Biology for premedical students
Histology
Histotechnology
Histochemistry
Advanced Histochistry
Research Project Course
Electron microscopy
Histocytotechnology
Invertebrate Zoology
Laboratory Technology: Urine, stool, blood, calculi and semen analysis
Poisonous Animals
Microtechnique
- Environmental Pollution
Anatomy course for Nursing students
Vertebrate Anatomy
Hematology
Animal Physiology
Zinc oxide nanoparticles (ZnO NPs) are widely used in industry and cosmetic products with promising investment in medical diagnosis and treatment. However, these particles may reveal a high potential risk for human health with no information about hepatotoxicity that might be associated with their exposure. The present work was carried out to investigate the histological and histochemical alterations induced in the hepatic tissues by naked 35nm ZnO NPs. Male Wistar albino rats were exposed to ZnO NPs at a daily dose of 2mg/kg for 21days. Liver biopsies from all rats under study were subjected to histopathological examinations. In comparison with the control rats, the following histological and histochemical alterations were demonstrated in the hepatic tissues of rats exposed to ZnO NPs: sinusoidal dilatation, Kupffer cells hyperplasia, lobular and portal triads inflammatory cells infiltration, necrosis, hydropic degeneration, hepatocytes apoptosis, anisokaryosis, karyolysis, nuclear membrane irregularity, glycogen content depletion and hemosidrosis. The findings of the present work might indicate that ZnO NPs have potential oxidative stress in the hepatic tissues that may affect the function of the liver. More work is needed to elucidate the toxicity and pathogenesis of zinc oxide nanoparticles on the vital organs.
Little is known about propolis protective effect against the toxicity induced by gold nanoparticles (GNPs). The present investigation was carried out to investigate the protective role of propolis against the histological alterations induced in the lung tissues by naked 10 nm GNPs. Male albino Wistar rats were exposed to 10 nm GNPs at a dose of 2 mg/kg together with or without propolis (50 mg/kg) for15 days. Lung biopsies from all rats under study were subjected to histological examinations. Exposure to 10 nm GNPs has induced thickened alveolar wall, inflammatory cells infiltration, interstitial macrophages invasion, emphysema, pulmonary edema, dilatation and congestion of the interalveolar capillaries, atelectasis and fibrocytes proliferation. Propolis combination with GNPs demonstrated full protection from pulmonary edema and alveolar hypersensitivity while the lung tissues were partially protected from interstitial thickening, inflammatory cells infiltration, emphysema, dilatation and congestion of the interalveolar capillaries. On the other hand, propolis failed to protect the lung tissues from fibrosis, macrophages invasion and atelectasis induced by GNPs. The findings indicated protective role for propolis against some histological damage in the pulmonary tissues induced by GNPs toxicity.
Male albino Wistar rats were exposed to 10 nm gold nanoparticles at a dose of 2000 µg/kg together with or without propolis (50 mg/kg) for 15 consecutive days. Fresh renal biopsies from of all investigated rats were cut rapidly, fixed in neutral buffered formalin, subjected to histological processing, and examined for microanatomical alterations. Propolis gave full protection against glomerular congestion and renal tubule hyaline casts. It demonstrated partial amelioration against glomerular capillary dilatation, tubular cloudy swelling, necrosis, and degeneration together with interstitial blood capillaries dilatation and haemorrhage induced by nanoparticle toxicity. On the other hand, propolis showed no protective effect against renal cells pyknosis, karyolysis, apoptosis and renal hydropic degeneration together with collecting tubules atrophy and degeneration induced by the nanoparticles. Thus propolis can augment the antioxidant defence against the severity of some alterations in the renal tissues. This ameliorative role might be related to the antioxidants content of propolis that protect the renal tissues from free radicals and oxidative stress.
Nanosilver is widely used in medicine, industry, and other applications where it poses a high potential risk for human health, even though little information is available on its toxicity to vital organs. This study was conducted to determine the histopathological changes induced in renal tissues by various sizes of silver nanoparticles (SNPs). Male BALB/C mice were exposed to various sizes of SNPs for 5 weeks. Renal tissue samples from all members of all experimental groups were subjected to histological processing and histopathological examination. SNPs caused glomerular and tubular alterations in the form of tubular degeneration, necrosis, eosinophilia, glomerular shrinkage, and Bowman’s capsule thickening. Moreover, SNPs induced interstitial intertubular regeneration, mononuclear inflammatory cell infiltration, proteinaceous casting, and fibrocyte proliferation. These results indicated that smaller particles (10 and 20 nm) were more toxic than the larger ones (40, 60, and 100 nm). In addition, the cortex was more affected than the medulla, and the proximal tubules were more affected than the distal ones. The results of the current investigation reveal that SNPs induce histomorphological alterations in renal tissues, with size being a key factor in the toxicity of these particles
Silver nanoparticles (SNPs) are widely used in nanomedicine and consuming products with potential risk to human health. While considerable work was carried out on the molecular, biochemical, and physiological alterations induced by these particles, little is known of the ultrastructural pathological alterations that might be induced by nanosilver materials. The aim of the present work is to investigate the hepatocyte ultrastructural alterations that might be induced by SNP exposure. Male rats were subjected to a daily single dose (2 mg/kg) of SNPs (15–35 nm diameter) for 21 days. Liver biopsies from all rats under study were processed for transmission electron microscopy examination. The following hepatic ultrastructural alterations were demonstrated: mitochondria swelling and crystolysis, endoplasmic reticulum disruption, cytoplasmic vacuolization, lipid droplets accumulation, glycogen depletion, karyopyknosis, apoptosis, sinusoidal dilatation, Kupffer cells activation, and myelin figures formation. The current findings may indicate that SNPs can induce hepatocyte organelles alteration, leading to cellular damage that may affect the function of the liver. These findings might indicate that SNPs potentially trigger heptocyte ultrastructural alterations that may affect the function of the liver with potential risk on human health in relation to numerous applications of these particles. More work is needed to elucidate probable ultrastructural alterations in the vital organs that might result from nanosilver toxicity.
Silver nanoparticles (SNPs) are widely invested in nanomedicine and consuming products due to their unique antimicrobial properties. However, little is known about the toxicity of these particles on human health. The present investigation was carried out to investigate the histological alterations induced in the lung tissues by 20±5 nm SNPs. Male albino Wistar rats were exposed to SNPs at a daily dose of 2 mg/kg for 21 days. Lung biopsies from all rats under study were subjected to histopathological examinations. Exposure to 20±5 nm SNPs induced the following pulmonary alterations: thickened alveolar wall, macrophages invasion and inflammatory cells infiltration, lymphatic follicles enlargement, pulmonary edema, alveolar hypersensitivity and interstitial congestion. Occasional atelectasis and fibrocytes proliferation were also detected. The findings of the present work might indicate that SNPs potentially trigger oxidative stress and alterations in the pulmonary tissues that may affect the function of the lungs.
Zinc oxide nanoparticles (ZnO NPs) are widely used in industry and cosmetic products with promising investment in medical diagnosis and treatment. However, these particles may reveal high potential risk for human health with little information is available about their toxicity. The present study was carried out to investigate the ultrastrcutural alterations induced in the hepatic tissues by ZnO NPs. Male Wistar albino rats were exposed to ZnO NPs at a daily dose of 2 mg/kg for 21 days. Furthermore, liver biopsies from all rats under study were subjected and processed for transmission electron microscopy and ultrastructural examination. Exposure to ZnO NPs has induced the following ultrastructural alterations: sinusoidal dilatation, Kupffer cells enlargement and activation, mitochondrial crystolysis and swelling, endoplasmic reticulum dilatation and vesiculation, myelin figures formation, karyopyknosis, nuclear membrane irregularity, chromatin fragmentation and glycogen depletion. These findings may suggest that ZnO NPs can induce ultrastructural alterations in the hepatic tissues resulted from disturbance of the pro-oxidant/antioxidant system leading to cellular alterations and affecting the liver functions. The results raise the concerns about the safety associated with ZnO NPs applications and highlight on the need to elucidate probable nanotoxicity that might be induced by these particles in the vital organs.
Silver nanoprticles (SNPs) are invested in medical, industrial and environmental applications. Little if any, is known about the morphometric alterations induced by the toxicity of SNPs. The aim of the present work is to find out the effect of variable size of SNPs on different morphometric parameters. Adult healthy male mice (BAL/C) were subjected to (10 nm, 20 nm, 40 nm 60 nm and 100 nm) SNPs for 35 days. Silver NPs caused non-significant decline on the average weight, significant decline in food consumption, increase in water intake, unilateral blindness, tanning fur color and cholestasis together with a decrease in the relative ratio of the liver, kidney and spleen weight to body weight. Mice subjected to 10 nm and 20 nm were more affected than mice receiving larger nanoparticles. These findings may indicate that SNPs could induce morphometric alterations that are size related wheresmaller SNPs have more impact than the larger ones.
Sildenafil is used for the treatment of erectile dysfunction and is helping millions of men around the world to achieve and maintain a long lasting erection. Fifty healthy male rabbits (Oryctolagus cuniculus) were used in the present study and exposed daily to sildenafil (0, 1, 3, 6, 9mg/kg) for 5 days per week for 7 weeks to investigate the biochemical changes and alterations in the hepatic tissues induced by this drug overdosing. In comparison with respective control rabbits, sildenafil overdoses elevated significantly (p-value<0.05, ANOVA test) alanine aminotransferase (ALT), aspartate aminotransferase (AST), testosterone, follicular stimulating hormone and total protein, while creatinine and urea were lowered with no significant alteration was observed in uric acid and luteinizing hormone concentration. Also sildenafil provoked hepatocytes nuclear alterations, necrosis, hydropic degeneration, bile duct hyperplasia, Kupffer cells hyperplasia, inflammatory cells infiltration, hepatic vessels congestion and evident partial depletion of glycogen content. The results show that subchronic exposure to sildenafil overdoses exhibits significant biochemical and alterations in the hepatic tissues that might affect the functions of the liver and other vital organs
All Rights Reseved © 2025 - Developed by: Prof. Mohammed M. Abu Shquier Editor: Ali Zreqat
